Chemicals and Drugs

Apolipoprotein C-III

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

18 entry terms
  • Apo C-III
  • Apolipoprotein CIII
  • Apo C III
  • Apolipoprotein C III
  • Apo C-III-2
  • ApoC-III
  • Apolipoprotein C-III-0
  • Apolipoprotein C-III-1
  • Sialyl Apo C-III
  • Sialyl Apolipoprotein C-III
  • Apo C III 2
  • Apo C-III, Sialyl
  • ApoC III
  • Apolipoprotein C III 0
  • Apolipoprotein C III 1
  • Apolipoprotein C-III, Sialyl
  • Sialyl Apo C III
  • Sialyl Apolipoprotein C III

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007; use APOLIPOPROTEIN C-III (NM) 1979-2006

MeSH Record

Previous Indexing

  • Apolipoproteins C (1977-2006)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.400w.875w
  2. D12.776w.070.400w.400w.875w
  3. D12.776w.521w.120w.400w.875w

AMA Style

References

  1. National Library of Medicine. Apolipoprotein C-III. Medical Subject Headings (MeSH). 2026. Unique ID D053305. http://id.nlm.nih.gov/mesh/2026/D053305
  2. Apolipoprotein C-III. In: Wikipedia. https://en.wikipedia.org/wiki/Apolipoprotein_C-III
  3. Apolipoprotein C-III. In: Wikidata. https://www.wikidata.org/wiki/Q14910515