Chemicals and Drugs

Apolipoprotein C-II

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

9 entry terms
  • Apo C-II
  • ApoC2
  • Apolipoprotein C-2
  • Apolipoprotein CII
  • Apoprotein C-II
  • Apo C II
  • Apolipoprotein C 2
  • Apolipoprotein C II
  • Apoprotein C II

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007; use APOLIPOPROTEIN C-II (NM) 1978-2006

MeSH Record

Previous Indexing

  • Apolipoproteins C (1977-2006)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.400w.750
  2. D12.776w.070.400w.400w.750
  3. D12.776w.521w.120w.400w.750

AMA Style

References

  1. National Library of Medicine. Apolipoprotein C-II. Medical Subject Headings (MeSH). 2026. Unique ID D053304. http://id.nlm.nih.gov/mesh/2026/D053304
  2. Apolipoprotein C-II. In: Wikidata. https://www.wikidata.org/wiki/Q24723057