Chemicals and Drugs

Aphidicolin

An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Chemical Identity

Chemical Information

Molecular Formula
C20H34O4
Molecular Weight
338.5 g/mol
CAS Registry No.
38966-21-1
IUPAC Name
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
InChIKey
NOFOAYPPHIUXJR-APNQCZIXSA-N
SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
MeSH Unique ID
D016590
Source
PubChem CID 457964

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
  • ICI-69653
  • NSC-234714
  • NSC-351140
  • ICI 69653
  • ICI69653
  • NSC 234714
  • NSC 351140
  • NSC234714
  • NSC351140

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was APHIDICOLIN (NM) 1974-91

MeSH Record

Previous Indexing

  • Antiviral Agents (1966-1991)
  • DNA Polymerases/antagonists & inhibitors (1977-1991)
  • Diterpenes (1974-1991)

MeSH Hierarchy

Tree Number

  1. D02w.455w.849w.291w.075w

AMA Style

References

  1. National Library of Medicine. Aphidicolin. Medical Subject Headings (MeSH). 2026. Unique ID D016590. http://id.nlm.nih.gov/mesh/2026/D016590
  2. Aphidicolin. In: Wikipedia. https://en.wikipedia.org/wiki/Aphidicolin
  3. Aphidicolin. In: Wikidata. https://www.wikidata.org/wiki/Q414000
  4. Aphidicolin. In: PubChem Compound. CID 457964. https://pubchem.ncbi.nlm.nih.gov/compound/457964