Phenomena and Processes

Antibody-Dependent Cell Cytotoxicity

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

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MeSH Record

Synonyms

15 entry terms
  • ADCC
  • Cell Cytoxicity, Antibody-Dependent
  • Cytotoxicity, Antibody-Dependent Cell
  • Antibody Dependent Cell Cytotoxicity
  • Antibody-Dependent Cell Cytotoxicities
  • Antibody-Dependent Cell Cytoxicities
  • Antibody-Dependent Cell Cytoxicity
  • Cell Cytotoxicities, Antibody-Dependent
  • Cell Cytotoxicity, Antibody-Dependent
  • Cell Cytoxicities, Antibody-Dependent
  • Cell Cytoxicity, Antibody Dependent
  • Cytotoxicities, Antibody-Dependent Cell
  • Cytotoxicity, Antibody Dependent Cell
  • Cytoxicities, Antibody-Dependent Cell
  • Cytoxicity, Antibody-Dependent Cell

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

78

MeSH Record

Previous Indexing

  • Cytotoxicity Tests, Immunologic (1971-1977)
  • Immunity, Cellular (1970-1977)
  • Lymphocytes (1966-1977)

MeSH Hierarchy

Tree Number

  1. G12.287.070w

MeSH Record

NLM Classification

QW 568

AMA Style

References

  1. National Library of Medicine. Antibody-Dependent Cell Cytotoxicity. Medical Subject Headings (MeSH). 2026. Unique ID D000920. http://id.nlm.nih.gov/mesh/2026/D000920
  2. Antibody-Dependent Cell Cytotoxicity. In: Wikipedia. https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity
  3. Antibody-Dependent Cell Cytotoxicity. In: Wikidata. https://www.wikidata.org/wiki/Q21418091