Chemicals and Drugs

Anistreplase

An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • APSAC
  • Anisoylated Plasminogen-Streptokinase Activator Complex
  • BRL-26921
  • Eminase
  • Iminase
  • BRL 26921
  • BRL26921

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Fibrinolytic Agents (1966-1990)
  • Plasminogen (1966-1990)
  • Streptokinase (1966-1990)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.635w.075w
  2. D08.811w.277w.656w.300w.775.075w
  3. D08.811w.277w.656w.959w.350.635w.075w
  4. D12.776w.124w.125.662w.537.075w

AMA Style

References

  1. National Library of Medicine. Anistreplase. Medical Subject Headings (MeSH). 2026. Unique ID D016255. http://id.nlm.nih.gov/mesh/2026/D016255
  2. Anistreplase. In: Wikipedia. https://en.wikipedia.org/wiki/Anistreplase
  3. Anistreplase. In: Wikidata. https://www.wikidata.org/wiki/Q4765471