Chemicals and Drugs

Angiotensinogen

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • Hypertensinogen
  • Proangiotensin
  • Renin-Substrate
  • SERPINA8
  • Serpin A8
  • Renin Substrate
  • Renin Substrate Tetradecapeptide
  • Tetradecapeptide, Renin Substrate

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

87(75); was see under ANGIOTENSINS 1975-86

MeSH Record

Previous Indexing

  • Alpha Globulins (1968-1974)
  • Angiotensin II (1968-1974)
  • Protein Precursors (1971-1974)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.456w.073w.070
  2. D12.644w.861w.020
  3. D12.776w.811w.070
  4. D12.776w.872w.020

MeSH Record

NLM Classification

QU 68

AMA Style

References

  1. National Library of Medicine. Angiotensinogen. Medical Subject Headings (MeSH). 2026. Unique ID D000808. http://id.nlm.nih.gov/mesh/2026/D000808
  2. Angiotensinogen. In: Wikidata. https://www.wikidata.org/wiki/Q24775136