Chemicals and Drugs

Angiotensin III

A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).

Chemical Identity

Chemical Information

Molecular Formula
C40H60N12O11
Molecular Weight
885.0 g/mol
IUPAC Name
(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
InChIKey
UCRMCWFIVZYPFA-LGXQCQDRSA-N
SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
MeSH Unique ID
D000805
Source
PubChem CID 44299731

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

5 entry terms
  • Des-Asp Angiotensin II
  • Des-Aspartyl-Angiotensin II
  • Angiotensin II, Des-Asp
  • Des Asp Angiotensin II
  • Des Aspartyl Angiotensin II

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(77); was see under ANGIOTENSIN II 1977-90

MeSH Record

Previous Indexing

  • Angiotensin II (1966-1976)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.094w.080
  2. D12.644w.400w.070w.080
  3. D12.644w.456w.073w.055
  4. D12.644w.548w.058w.080
  5. D12.776w.631w.650w.070w.080
  6. D23.469.050w.050w.075

AMA Style

References

  1. National Library of Medicine. Angiotensin III. Medical Subject Headings (MeSH). 2026. Unique ID D000805. http://id.nlm.nih.gov/mesh/2026/D000805
  2. Angiotensin III. In: Wikidata. https://www.wikidata.org/wiki/Q27074467
  3. Angiotensin III. In: PubChem Compound. CID 44299731. https://pubchem.ncbi.nlm.nih.gov/compound/44299731