Structured Summary
Abstract
A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women.
Chemical Identity
Chemical Information
- Molecular Formula
- C17H19N5
- Molecular Weight
- 293.4 g/mol
- CAS Registry No.
- 120511-73-1
- IUPAC Name
- 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
- InChIKey
- YBBLVLTVTVSKRW-UHFFFAOYSA-N
- SMILES
- CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
- MeSH Unique ID
- D000077384
- Source
- PubChem CID 2187
MeSH Record
Classification
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile)
- Anastrazole
- Arimidex
- ICI D1033
- ZD-1033
- ZD1033
- Zeneca ZD 1033
- ZD 1033
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1994)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Anastrozole. Medical Subject Headings (MeSH). 2026. Unique ID D000077384. http://id.nlm.nih.gov/mesh/2026/D000077384
- Anastrozole. In: Wikipedia. https://en.wikipedia.org/wiki/Anastrozole
- Anastrozole. In: Wikidata. https://www.wikidata.org/wiki/Q419143
- Anastrozole. In: PubChem Compound. CID 2187. https://pubchem.ncbi.nlm.nih.gov/compound/2187