Chemicals and Drugs

Anaplastic Lymphoma Kinase

A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • ALK Kinase
  • ALK Tyrosine Kinase Receptor
  • Anaplastic Lymphoma Receptor Tyrosine Kinase
  • CD246 Antigen
  • NPM-ALK
  • Nucleophosmin-Anaplastic Lymphoma Kinase
  • Nucleophosmin Anaplastic Lymphoma Kinase

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.002
  2. D12.776w.476.568w.400w.002
  3. D12.776w.543w.750w.630w.002

AMA Style

References

  1. National Library of Medicine. Anaplastic Lymphoma Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D000077548. http://id.nlm.nih.gov/mesh/2026/D000077548
  2. Anaplastic Lymphoma Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q24786209