Structured Summary
Abstract
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
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Synonyms
11 entry terms
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
- Amyloid beta Precursor Protein
- Protease Nexin 2
- Protease Nexin II
- beta-Amyloid Protein Precursor
- Amyloid beta Protein Precursor
- Nexin 2, Protease
- Nexin II, Protease
- beta Amyloid Protein Precursor
- beta-Protein Precursor, Amyloid
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94
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Previous Indexing
- Amyloid (1988-1991)
- Protein Precursors (1988-1991)
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AMA Style
References
- National Library of Medicine. Amyloid beta-Protein Precursor. Medical Subject Headings (MeSH). 2026. Unique ID D016564. http://id.nlm.nih.gov/mesh/2026/D016564
- Amyloid beta-Protein Precursor. In: Wikidata. https://www.wikidata.org/wiki/Q24779223