Chemicals and Drugs

Amiodarone

An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.

Chemical Identity

Chemical Information

Molecular Formula
C25H29I2NO3
Molecular Weight
645.3 g/mol
CAS Registry No.
1951-25-3
IUPAC Name
(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone
InChIKey
IYIKLHRQXLHMJQ-UHFFFAOYSA-N
SMILES
CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
MeSH Unique ID
D000638
Source
PubChem CID 2157

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

22 entry terms
  • Amiobeta
  • Amiodarex
  • Amiodarona
  • Amiodarone Hydrochloride
  • Amiohexal
  • Aratac
  • Braxan
  • Corbionax
  • Cordarex
  • Cordarone
  • Kordaron
  • L-3428
  • Ortacrone
  • Rytmarone
  • SKF 33134-A
  • Tachydaron
  • Trangorex
  • Hydrochloride, Amiodarone
  • L 3428
  • L3428
  • SKF 33134 A
  • SKF 33134A

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87(75); was see under BENZOFURANS 1975-86

MeSH Record

Previous Indexing

  • Benzofurans (1968-1974)
  • Diethylamines (1974)
  • Iodobenzoates (1973-1974)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.127w.075w

MeSH Record

NLM Classification

QV 150

AMA Style

References

  1. National Library of Medicine. Amiodarone. Medical Subject Headings (MeSH). 2026. Unique ID D000638. http://id.nlm.nih.gov/mesh/2026/D000638
  2. Amiodarone. In: Wikipedia. https://en.wikipedia.org/wiki/Amiodarone
  3. Amiodarone. In: Wikidata. https://www.wikidata.org/wiki/Q410061
  4. Amiodarone. In: PubChem Compound. CID 2157. https://pubchem.ncbi.nlm.nih.gov/compound/2157