Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Amino Acid Substitution

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

MeSH Record

Classification

Broader headings

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See Also

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Synonyms

3 entry terms
  • Amino Acid Substitutions
  • Substitution, Amino Acid
  • Substitutions, Amino Acid

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

98

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1966-1997)

MeSH Hierarchy

Tree Numbers

  1. E05.393.420w.601w.035w
  2. G05.558w.109w

AMA Style

References

  1. National Library of Medicine. Amino Acid Substitution. Medical Subject Headings (MeSH). 2026. Unique ID D019943. http://id.nlm.nih.gov/mesh/2026/D019943
  2. Amino Acid Substitution. In: Wikipedia. https://en.wikipedia.org/wiki/Amino_acid_replacement
  3. Amino Acid Substitution. In: Wikidata. https://www.wikidata.org/wiki/Q30693176