Chemicals and Drugs

Amiloride

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Chemical Identity

Chemical Information

Molecular Formula
C6H8ClN7O
Molecular Weight
229.63 g/mol
CAS Registry No.
2609-46-3
IUPAC Name
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-N
SMILES
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
MeSH Unique ID
D000584
Source
PubChem CID 16231

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • Amidal
  • Amiduret Trom
  • Amiloberag
  • Amiloride Hydrochloride
  • Amiloride Hydrochloride, Anhydrous
  • Kaluril
  • Midamor
  • Midoride
  • Modamide
  • Anhydrous Amiloride Hydrochloride
  • Hydrochloride, Amiloride
  • Hydrochloride, Anhydrous Amiloride
  • Trom, Amiduret

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86(72); was see under PYRAZINES 1975-85, was Prov 1972-74

MeSH Record

Previous Indexing

  • Diuretics (1966-1971)
  • Pyrazines (1966-1971)

MeSH Hierarchy

Tree Number

  1. D03w.383.679.149w

MeSH Record

NLM Classification

QV 160

AMA Style

References

  1. National Library of Medicine. Amiloride. Medical Subject Headings (MeSH). 2026. Unique ID D000584. http://id.nlm.nih.gov/mesh/2026/D000584
  2. Amiloride. In: Wikipedia. https://en.wikipedia.org/wiki/Amiloride
  3. Amiloride. In: Wikidata. https://www.wikidata.org/wiki/Q419995
  4. Amiloride. In: PubChem Compound. CID 16231. https://pubchem.ncbi.nlm.nih.gov/compound/16231