Structured Summary
Abstract
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
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Classification
Broader headings
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Synonyms
4 entry terms
- Alternative Complement Activation Pathway
- Complement Activation Pathway, Alternative
- Complement Pathway, Alternative
- Properdin Pathway
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
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History Note
91(79); was see under COMPLEMENT ACTIVATION 1979-90
MeSH Record
Previous Indexing
- Complement (1966-1978)
- Complement Fixation Tests (1966-1978)
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AMA Style
References
- National Library of Medicine. Alternative Complement Pathway. Medical Subject Headings (MeSH). 2026. Unique ID D003170. http://id.nlm.nih.gov/mesh/2026/D003170
- Alternative Complement Pathway. In: Wikipedia. https://en.wikipedia.org/wiki/Alternative_complement_pathway
- Alternative Complement Pathway. In: Wikidata. https://www.wikidata.org/wiki/Q4736500