Structured Summary
Abstract
Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
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Classification
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
2 entry terms
- Alkyl Estrogenic Steroids
- Estrogenic Steroids, Alkylated
MeSH Record
Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2004
MeSH Record
Previous Indexing
- Ethinyl Estradiol (1968-2003)
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AMA Style
References
- National Library of Medicine. Alkylated Estrogenic Steroids. Medical Subject Headings (MeSH). 2026. Unique ID D042782. http://id.nlm.nih.gov/mesh/2026/D042782
- Alkylated Estrogenic Steroids. In: Wikidata. https://www.wikidata.org/wiki/Q78439231