Chemicals and Drugs

Aldo-Keto Reductase Family 1 Member C3

Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

5 entry terms
  • 17-beta-Hydroxysteroid Dehydrogenase Type 5
  • AKR1C3 Protein
  • Dihydrodiol Dehydrogenase 3
  • 17 beta Hydroxysteroid Dehydrogenase Type 5
  • Aldo Keto Reductase Family 1 Member C3

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • 3-Hydroxysteroid Dehydrogenases (2004-2017)
  • Hydroxyprostaglandin Dehydrogenases (2004-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.047w.150w.700.156w.875
  2. D08.811w.682w.047w.436w.375w.140
  3. D08.811w.682w.047w.820.284w.937
  4. D08.811w.682w.047w.820.375.500

AMA Style

References

  1. National Library of Medicine. Aldo-Keto Reductase Family 1 Member C3. Medical Subject Headings (MeSH). 2026. Unique ID D000074425. http://id.nlm.nih.gov/mesh/2026/D000074425
  2. Aldo-Keto Reductase Family 1 Member C3. In: Wikidata. https://www.wikidata.org/wiki/Q21105060