Structured Summary
Abstract
Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).
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Classification
Broader headings
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MeSH Record
Synonyms
5 entry terms
- AKR1C2 Protein
- Dihydrodiol Dehydrogenase 2
- Dihydrodiol Dehydrogenase-Bile Acid Binding Protein
- Aldo Keto Reductase Family 1 Member C2
- Dihydrodiol Dehydrogenase Bile Acid Binding Protein
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Hydroxysteroid Dehydrogenases (2001-2017)
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AMA Style
References
- National Library of Medicine. Aldo-Keto Reductase Family 1 Member C2. Medical Subject Headings (MeSH). 2026. Unique ID D000074422. http://id.nlm.nih.gov/mesh/2026/D000074422
- Aldo-Keto Reductase Family 1 Member C2. In: Wikidata. https://www.wikidata.org/wiki/Q21105063