Structured Summary
Abstract
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
6 entry terms
- Alarmin
- Alarmin Proteins
- Damage-Associated Molecular Pattern Molecules
- Danger-Associated Molecular Pattern Molecules
- Damage Associated Molecular Pattern Molecules
- Danger Associated Molecular Pattern Molecules
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2016
MeSH Record
Previous Indexing
- HMGB1 Protein (2004-2015)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Alarmins. Medical Subject Headings (MeSH). 2026. Unique ID D000067531. http://id.nlm.nih.gov/mesh/2026/D000067531
- Alarmins. In: Wikipedia. https://en.wikipedia.org/wiki/Damage-associated_molecular_pattern
- Alarmins. In: Wikidata. https://www.wikidata.org/wiki/Q3325172