Chemicals and Drugs

Activating Transcription Factor 6

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • ATF6 Transcription Factor
  • Transcription Factor, ATF6

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1997)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.011
  2. D12.776w.260w.108.061w.968
  3. D12.776w.476.011
  4. D12.776w.930w.127.061w.968

AMA Style

References

  1. National Library of Medicine. Activating Transcription Factor 6. Medical Subject Headings (MeSH). 2026. Unique ID D051702. http://id.nlm.nih.gov/mesh/2026/D051702
  2. Activating Transcription Factor 6. In: Wikidata. https://www.wikidata.org/wiki/Q24769165