Chemicals and Drugs

Acitretin

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.

Chemical Identity

Chemical Information

Molecular Formula
C21H26O3
Molecular Weight
326.4 g/mol
CAS Registry No.
55079-83-9
IUPAC Name
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
InChIKey
IHUNBGSDBOWDMA-AQFIFDHZSA-N
SMILES
CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC
MeSH Unique ID
D017255
Source
PubChem CID 5284513

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Etretin
  • 13-cis-Acitretin
  • Acitretin, (Z,E,E,E)-Isomer
  • Isoacitretin
  • Isoetretin
  • Neotigason
  • Ro 10-1670
  • Ro 13-7652
  • Ro-10-1670
  • Ro-13-7652
  • Soriatane
  • Ro 101670
  • Ro 137652
  • Ro101670
  • Ro137652

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was ACITRETIN (NM) 1977-91

MeSH Record

Previous Indexing

  • Tretinoin/analogs & derivatives (1977-1992)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.326.271w.665w.202w.495w.050w
  2. D02w.455w.849w.131w.495w.050w
  3. D23.767w.261w.700w.050w

AMA Style

References

  1. National Library of Medicine. Acitretin. Medical Subject Headings (MeSH). 2026. Unique ID D017255. http://id.nlm.nih.gov/mesh/2026/D017255
  2. Acitretin. In: Wikipedia. https://en.wikipedia.org/wiki/Acitretin
  3. Acitretin. In: Wikidata. https://www.wikidata.org/wiki/Q341500
  4. Acitretin. In: PubChem Compound. CID 5284513. https://pubchem.ncbi.nlm.nih.gov/compound/5284513