Chemicals and Drugs

Acetolactate Synthase

A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.

MeSH Record

Classification

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MeSH Record

Synonyms

13 entry terms
  • Acetohydroxy Acid Synthase
  • Acetohydroxy Acid Synthetase
  • Acetolactate Synthetase
  • Acid Synthase, Acetohydroxy
  • Acid Synthetase, Acetohydroxy
  • Synthase, Acetohydroxy Acid
  • Synthase, Acetolactate
  • Synthetase, Acetohydroxy Acid
  • Synthetase, Acetolactate
  • Acetohydroxyacid Synthetase I
  • Acetoxyhydroxyacid Synthase III
  • Synthase III, Acetoxyhydroxyacid
  • Synthetase I, Acetohydroxyacid

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(75); was see under KETOACID-LYASES 1975-90

MeSH Record

Previous Indexing

  • Ketoacid-Lyases (1972-1974)
  • Pyruvates (1972-1974)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Acetolactate Synthase. Medical Subject Headings (MeSH). 2026. Unique ID D000095. http://id.nlm.nih.gov/mesh/2026/D000095
  2. Acetolactate Synthase. In: Wikipedia. https://en.wikipedia.org/wiki/Acetolactate_synthase
  3. Acetolactate Synthase. In: Wikidata. https://www.wikidata.org/wiki/Q2823839