Chemicals and Drugs

Abuse-Deterrent Formulations

Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED SUBSTANCES. These may include physical barriers to prevent chewing or crushing the drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist combinations to reduce euphoria associated with abuse; aversion, where controlled substances are combined with others that will produce an unpleasant effect if the patient manipulates the dosage form or exceeds the recommended dose; delivery systems that are resistant to abuse such as implants; or combinations of these methods.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED SUBSTANCES. These may include physical barriers to prevent chewing or crushing the drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist combinations to reduce euphoria associated with abuse; aversion, where controlled substances are combined with others that will produce an unpleasant effect if the patient manipulates the dosage form or exceeds the recommended dose; delivery systems that are resistant to abuse such as implants; or combinations of these methods.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

5 entry terms
  • Abuse-Deterrent Formulation
  • Abuse Deterrent Formulation
  • Abuse Deterrent Formulations
  • Formulation, Abuse-Deterrent
  • Formulations, Abuse-Deterrent

MeSH Record

Aspects Covered

14 allowable subheadings

Indexed with the subheadings adverse effects, classification, economics, ethics, history, instrumentation, methods, mortality, nursing, psychology, standards, statistics & numerical data, trends, veterinary.

MeSH Record

History Note

2018

MeSH Hierarchy

Tree Numbers

  1. D26.255w.075
  2. D27.505.696.034
  3. D27.505.696.663.850.007
  4. D27.505.954.427.005
  5. E02w.319w.300.127
  6. E05.916w.250w.500

AMA Style

References

  1. National Library of Medicine. Abuse-Deterrent Formulations. Medical Subject Headings (MeSH). 2026. Unique ID D000075162. http://id.nlm.nih.gov/mesh/2026/D000075162
  2. Abuse-Deterrent Formulations. In: Wikidata. https://www.wikidata.org/wiki/Q50429629