Chemicals and Drugs

AMP-Activated Protein Kinases

Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

20 entry terms
  • 5'-AMP-Activated Protein Kinase
  • AMP-Activated Kinase
  • AMP-Activated Protein Kinase
  • 5' AMP Activated Protein Kinase
  • AMP Activated Kinase
  • AMP Activated Protein Kinase
  • AMP Activated Protein Kinases
  • AMP-Activated Protein Kinase alpha Subunit
  • AMP-Activated Protein Kinase alpha Subunits
  • AMP-Activated Protein Kinase beta Subunit
  • AMP-Activated Protein Kinase beta Subunits
  • AMP-Activated Protein Kinase gamma Subunit
  • AMP-Activated Protein Kinase gamma Subunits
  • PRKAA
  • AMP Activated Protein Kinase alpha Subunit
  • AMP Activated Protein Kinase alpha Subunits
  • AMP Activated Protein Kinase beta Subunit
  • AMP Activated Protein Kinase beta Subunits
  • AMP Activated Protein Kinase gamma Subunit
  • AMP Activated Protein Kinase gamma Subunits

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2009(1980)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.085w
  2. D12.776w.476.563w.085w

AMA Style

References

  1. National Library of Medicine. AMP-Activated Protein Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D055372. http://id.nlm.nih.gov/mesh/2026/D055372
  2. AMP-Activated Protein Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/AMP-activated_protein_kinase
  3. AMP-Activated Protein Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q295240