Chemicals and Drugs

AIRE Protein

A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • APECED Protein
  • Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein
  • Autoimmune Regulator Protein
  • Protein, AIRE
  • Protein, APECED
  • Protein, Autoimmune Regulator
  • Regulator Protein, Autoimmune

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024 (1997)

MeSH Hierarchy

Tree Number

  1. D12.776w.930w.123

AMA Style

References

  1. National Library of Medicine. AIRE Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000096927. http://id.nlm.nih.gov/mesh/2026/D000096927
  2. AIRE Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24783415