Chemicals and Drugs

ADAM17 Protein

A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

18 entry terms
  • ADAM-17
  • ADAM-17 Protein
  • CD156b Antigen
  • Disintegrin and Metalloproteinase Domain-Containing Protein 17
  • TACA (Enzyme)
  • TACE (Enzyme)
  • TNF-alpha Convertase
  • TNF-alpha Converting Enzyme
  • Tumor Necrosis Factor Alpha Convertase
  • Tumor Necrosis Factor-alpha Convertase
  • Tumor Necrosis Factor-alpha Converting Enzyme
  • ADAM 17 Protein
  • Antigen, CD156b
  • Convertase, TNF-alpha
  • Disintegrin and Metalloproteinase Domain Containing Protein 17
  • TNF alpha Convertase
  • TNF alpha Converting Enzyme
  • Tumor Necrosis Factor alpha Converting Enzyme

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1996)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.675w.374w.102w.375
  2. D09w.400w.430w.500w.375
  3. D12.776w.395w.033w.375

AMA Style

References

  1. National Library of Medicine. ADAM17 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000072198. http://id.nlm.nih.gov/mesh/2026/D000072198
  2. ADAM17 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21149323