Structured Summary
Abstract
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
See Also
MeSH Record
Synonyms
18 entry terms
- AC133-1 Antigen
- CD133 Antigen
- Fudenine
- PROML1
- Prominin
- Prominin-1
- Prominin-Like PROML1
- AC133 1 Antigen
- Antigen, AC133
- Antigen, AC133-1
- Antigen, CD133
- Prominin 1
- Prominin Like PROML1
- AC133-2 Antigen
- AC141 Antigen
- AC133 2 Antigen
- Antigen, AC133-2
- Antigen, AC141
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017(1998)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. AC133 Antigen. Medical Subject Headings (MeSH). 2026. Unique ID D000071916. http://id.nlm.nih.gov/mesh/2026/D000071916
- AC133 Antigen. In: Wikidata. https://www.wikidata.org/wiki/Q24721841