Structured Summary
Abstract
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
15 entry terms
- 5-Aminolevulinate Synthase
- Aminolevulinic Acid Synthetase
- delta-Aminolevulinate Synthase
- delta-Aminolevulinic Acid Synthetase
- 5 Aminolevulinate Synthase
- 5 Aminolevulinate Synthetase
- Acid Synthetase, Aminolevulinic
- Acid Synthetase, delta-Aminolevulinic
- Synthase, 5-Aminolevulinate
- Synthase, delta-Aminolevulinate
- Synthetase, 5-Aminolevulinate
- Synthetase, Aminolevulinic Acid
- Synthetase, delta-Aminolevulinic Acid
- delta Aminolevulinate Synthase
- delta Aminolevulinic Acid Synthetase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
98(72)
MeSH Record
Previous Indexing
- Acyltransferases (1966-1971)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. 5-Aminolevulinate Synthetase. Medical Subject Headings (MeSH). 2026. Unique ID D000624. http://id.nlm.nih.gov/mesh/2026/D000624
- 5-Aminolevulinate Synthetase. In: Wikidata. https://www.wikidata.org/wiki/Q76539507