Chemicals and Drugs

4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine

A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.

Chemical Identity

Chemical Information

Molecular Formula
C10H10F3N3
Molecular Weight
229.20 g/mol
CAS Registry No.
66000-40-6
IUPAC Name
2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine
InChIKey
CPXGGWXJNQSFEP-UHFFFAOYSA-N
SMILES
C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F
MeSH Unique ID
D015772
Source
PubChem CID 47795

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • BW-755C
  • BW755C
  • BW 755C

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2005(1991)

MeSH Record

Previous Indexing

  • Anti-Inflammatory Agents (1966-1986)
  • Anti-Inflammatory Agents, Non-Steroidal (1987-1989)
  • Pyrazoles (1966-1989)

MeSH Hierarchy

Tree Number

  1. D03w.383.129w.539.180

AMA Style

References

  1. National Library of Medicine. 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine. Medical Subject Headings (MeSH). 2026. Unique ID D015772. http://id.nlm.nih.gov/mesh/2026/D015772
  2. 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine. In: Wikidata. https://www.wikidata.org/wiki/Q27265569
  3. 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine. In: PubChem Compound. CID 47795. https://pubchem.ncbi.nlm.nih.gov/compound/47795