Chemicals and Drugs

4-Hydroxycoumarins

Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.

MeSH Record

Classification

Broader headings

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • 4 Hydroxycoumarins

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/biosyn permitted if by plant

MeSH Record

History Note

77

MeSH Record

Previous Indexing

  • Coumarins (1972-1976)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.663.283.446w.520w
  2. D03w.633.100.150.446w.520w

AMA Style

References

  1. National Library of Medicine. 4-Hydroxycoumarins. Medical Subject Headings (MeSH). 2026. Unique ID D015110. http://id.nlm.nih.gov/mesh/2026/D015110
  2. 4-Hydroxycoumarins. In: Wikipedia. https://en.wikipedia.org/wiki/4-Hydroxycoumarins
  3. 4-Hydroxycoumarins. In: Wikidata. https://www.wikidata.org/wiki/Q3599051