Chemicals and Drugs

3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

14 entry terms
  • 3 alpha-Hydroxysteroid Dehydrogenase
  • 3 alpha-Hydroxysteroid Dehydrogenase (B-Specific)
  • 3 alpha-Hydroxysteroid Oxidoreductase
  • 3alpha-Hydroxysteroid Dehydrogenase (B-specific)
  • 3 alpha Hydroxysteroid Dehydrogenase
  • 3 alpha Hydroxysteroid Oxidoreductase
  • Dehydrogenase, 3 alpha-Hydroxysteroid
  • Oxidoreductase, 3 alpha-Hydroxysteroid
  • 5 alpha-3 alpha-Hydroxysteroid Dehydrogenase
  • 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
  • 5-DP-3 alpha-HSO
  • NADPH-5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
  • 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase
  • NADPH 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC) (NM) 1979-2003

MeSH Record

Previous Indexing

  • 3-Hydroxysteroid Dehydrogenases (1979-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.047w.436w.350w.100w
  2. D08.811w.682w.047w.820.186w

AMA Style

References

  1. National Library of Medicine. 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific). Medical Subject Headings (MeSH). 2026. Unique ID D045002. http://id.nlm.nih.gov/mesh/2026/D045002
  2. 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific). In: Wikipedia. https://en.wikipedia.org/wiki/3alpha-hydroxysteroid_dehydrogenase_(B-specific)
  3. 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific). In: Wikidata. https://www.wikidata.org/wiki/Q1143648