Chemicals and Drugs

3-Phosphoinositide-Dependent Protein Kinases

Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

19 entry terms
  • 3-Phosphoinositide-Dependent Protein Kinase
  • 3 Phosphoinositide Dependent Protein Kinase
  • 3 Phosphoinositide Dependent Protein Kinases
  • Kinase, 3-Phosphoinositide-Dependent Protein
  • Kinases, 3-Phosphoinositide-Dependent Protein
  • Protein Kinase, 3-Phosphoinositide-Dependent
  • Protein Kinases, 3-Phosphoinositide-Dependent
  • 3-Phosphoinositide Dependent Protein Kinase-1
  • 3-Phosphoinositide Dependent Protein Kinase-2
  • 3-Phosphoinositide-Dependent Kinase 1 (PDK1)
  • 3-Phosphoinositide-Dependent Protein Kinase-1
  • 3-Phosphoinositide-Dependent Protein Kinase-2
  • PtdIns(3,4,5)P3-Dependent Protein Kinase-1
  • 3 Phosphoinositide Dependent Protein Kinase 1
  • 3 Phosphoinositide Dependent Protein Kinase 2
  • Kinase-1, 3-Phosphoinositide-Dependent Protein
  • Kinase-2, 3-Phosphoinositide-Dependent Protein
  • Protein Kinase-1, 3-Phosphoinositide-Dependent
  • Protein Kinase-2, 3-Phosphoinositide-Dependent

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (1997-2013)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.745
  2. D12.776w.476.563w.745

AMA Style

References

  1. National Library of Medicine. 3-Phosphoinositide-Dependent Protein Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D064413. http://id.nlm.nih.gov/mesh/2026/D064413
  2. 3-Phosphoinositide-Dependent Protein Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q78035411