Chemicals and Drugs

3-Isopropylmalate Dehydrogenase

An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. It is involved in the biosynthesis of VALINE; LEUCINE; and ISOLEUCINE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. It is involved in the biosynthesis of VALINE; LEUCINE; and ISOLEUCINE.

MeSH Record

Classification

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MeSH Record

Synonyms

8 entry terms
  • beta-IPM Dehydrogenase
  • beta-Isopropylmalate Dehydrogenase
  • 3 Isopropylmalate Dehydrogenase
  • Dehydrogenase, 3-Isopropylmalate
  • Dehydrogenase, beta-IPM
  • Dehydrogenase, beta-Isopropylmalate
  • beta IPM Dehydrogenase
  • beta Isopropylmalate Dehydrogenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1980); use DICARBOXYLIC ACIDS 1970-1979

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AMA Style

References

  1. National Library of Medicine. 3-Isopropylmalate Dehydrogenase. Medical Subject Headings (MeSH). 2026. Unique ID D050539. http://id.nlm.nih.gov/mesh/2026/D050539
  2. 3-Isopropylmalate Dehydrogenase. In: Wikipedia. https://en.wikipedia.org/wiki/3-Isopropylmalate_dehydrogenase
  3. 3-Isopropylmalate Dehydrogenase. In: Wikidata. https://www.wikidata.org/wiki/Q24740415