Chemicals and Drugs

2',5'-Oligoadenylate Synthetase

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

16 entry terms
  • (2'-5')An Polymerase
  • 2',5'-Oligo(A) Polymerase
  • 2',5'-Oligo(A) Synthetase
  • 2',5'-Oligoadenylate Polymerase
  • 2,5 Oligoadenylate Polymerase
  • 2,5 Oligoadenylate Synthetase
  • 2-5A Synthetase
  • ATP-(2'-5')oligo(A)adenylyltransferase
  • 2',5' Oligoadenylate Polymerase
  • 2',5' Oligoadenylate Synthetase
  • Oligoadenylate Polymerase, 2,5
  • Oligoadenylate Synthetase, 2,5
  • Polymerase, 2',5'-Oligoadenylate
  • Polymerase, 2,5 Oligoadenylate
  • Synthetase, 2',5'-Oligoadenylate
  • Synthetase, 2,5 Oligoadenylate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

83

MeSH Record

Previous Indexing

  • Nucleotidyltransferases (1966-1982)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.445w.625w

MeSH Record

NLM Classification

QU 141

AMA Style

References

  1. National Library of Medicine. 2',5'-Oligoadenylate Synthetase. Medical Subject Headings (MeSH). 2026. Unique ID D015088. http://id.nlm.nih.gov/mesh/2026/D015088
  2. 2',5'-Oligoadenylate Synthetase. In: Wikipedia. https://en.wikipedia.org/wiki/2%27-5%27-oligoadenylate_synthase
  3. 2',5'-Oligoadenylate Synthetase. In: Wikidata. https://www.wikidata.org/wiki/Q4596725