Chemicals and Drugs

24,25-Dihydroxyvitamin D 3

A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL.

Chemical Identity

Chemical Information

Molecular Formula
C27H44O3
Molecular Weight
416.6 g/mol
IUPAC Name
(6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
InChIKey
FCKJYANJHNLEEP-OIMXRAFZSA-N
SMILES
C[C@H](CCC(C(C)(C)O)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@@H](CCC3=C)O)C
MeSH Unique ID
D015650
Source
PubChem CID 12895043

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • 24,25 Dihydroxyvitamin D3
  • 24,25-Dihydroxycholecalciferol
  • 24,25-Dihydroxyvitamin D3
  • 24,25 Dihydroxycholecalciferol
  • 24,25 Dihydroxyvitamin D 3
  • Dihydroxyvitamin D3, 24,25
  • (24R)-24,25-Dihydroxyvitamin D3
  • 24,25-Dihydroxyvitamin D 3, (3beta,5Z,7E,24R)-Isomer
  • 24R,25-Dihydroxycholecalciferol
  • 24R,25 Dihydroxycholecalciferol

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

deficiency: coordinate 24,25-DIHYDROXYVITAMIN D 3 /defic (IM) with RICKETS (IM) or with VITAMIN D DEFICIENCY (IM)

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Dihydroxycholecalciferols (1973-1989)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.247.222w.159w.478w.387w.400
  2. D04w.210.500w.247.808w.146w.478w.387w.400
  3. D04w.210.500w.812w.768w.196w.478w.387w.400
  4. D10w.570w.938w.146w.478w.387w.400

AMA Style

References

  1. National Library of Medicine. 24,25-Dihydroxyvitamin D 3. Medical Subject Headings (MeSH). 2026. Unique ID D015650. http://id.nlm.nih.gov/mesh/2026/D015650
  2. 24,25-Dihydroxyvitamin D 3. In: Wikidata. https://www.wikidata.org/wiki/Q27161510
  3. 24,25-Dihydroxyvitamin D 3. In: PubChem Compound. CID 12895043. https://pubchem.ncbi.nlm.nih.gov/compound/12895043