Chemicals and Drugs

2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine

A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

15 entry terms
  • Collagen Lysyl Hydroxylase
  • Lysine 2-Oxoglutarate Dioxygenase
  • Lysine Hydroxylase
  • Lysyl Hydroxylase
  • Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
  • Protocollagen Lysyl Hydroxylase
  • 2-Oxoglutarate Dioxygenase, Lysine
  • 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate
  • Dioxygenase, Lysine 2-Oxoglutarate
  • Hydroxylase, Collagen Lysyl
  • Hydroxylase, Lysine
  • Hydroxylase, Lysyl
  • Hydroxylase, Protocollagen Lysyl
  • Lysine 2 Oxoglutarate Dioxygenase
  • Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

92; was LYSINE HYDROXYLASE 1977-91 (see under HYDROXYLASES 1977-90)

MeSH Record

Previous Indexing

  • Hydroxylases (1966-1976)
  • Ketoglutaric Acids (1966-1976)
  • Lysine (1966-1976)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.690w.708.660w

AMA Style

References

  1. National Library of Medicine. 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine. Medical Subject Headings (MeSH). 2026. Unique ID D008240. http://id.nlm.nih.gov/mesh/2026/D008240
  2. 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine. In: Wikipedia. https://en.wikipedia.org/wiki/Lysyl_hydroxylase
  3. 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine. In: Wikidata. https://www.wikidata.org/wiki/Q368589