Chemicals and Drugs

2-Acetylaminofluorene

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Chemical Identity

Chemical Information

Molecular Formula
C15H13NO
Molecular Weight
223.27 g/mol
CAS Registry No.
53-96-3
IUPAC Name
N-(9H-fluoren-2-yl)acetamide
InChIKey
CZIHNRWJTSTCEX-UHFFFAOYSA-N
SMILES
CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2
MeSH Unique ID
D015073
Source
PubChem CID 5897

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • 2-AAF
  • 2-Acetamidofluorene
  • 2-Fluorenylacetamide
  • AAF, Aminofluorene
  • Fluoren-2-ylacetamide
  • N-2-Fluorenylacetamide
  • N-Acetyl-2-Aminofluorene
  • 2 Acetamidofluorene
  • 2 Acetylaminofluorene
  • 2 Fluorenylacetamide
  • Aminofluorene AAF
  • Fluoren 2 ylacetamide
  • N 2 Fluorenylacetamide
  • N Acetyl 2 Aminofluorene
  • Acetylaminofluorene

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

83; was ACETYLAMINOFLUORENE 1980-82; was ACETYLAMINOFLUORENE see under FLUORENES 1975-79

MeSH Record

Previous Indexing

  • Acetamides (1971-1974)
  • Fluorenes (1966-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.064.150w
  2. D02w.241w.081.018w.110.080w
  3. D02w.455w.426w.559w.847w.389.050w
  4. D04w.615w.389.050w

AMA Style

References

  1. National Library of Medicine. 2-Acetylaminofluorene. Medical Subject Headings (MeSH). 2026. Unique ID D015073. http://id.nlm.nih.gov/mesh/2026/D015073
  2. 2-Acetylaminofluorene. In: Wikipedia. https://en.wikipedia.org/wiki/2-Acetylaminofluorene
  3. 2-Acetylaminofluorene. In: Wikidata. https://www.wikidata.org/wiki/Q4382200
  4. 2-Acetylaminofluorene. In: PubChem Compound. CID 5897. https://pubchem.ncbi.nlm.nih.gov/compound/5897