Chemicals and Drugs

15-Oxoprostaglandin 13-Reductase

(5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

(5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

17 entry terms
  • 15-Ketoprostaglandin delta 13-Reductase
  • Prostaglandin delta-13-Reductase
  • Prostaglandin-13,14-Reductase
  • delta 13-15-Ketoprostaglandin Reductase
  • delta-13-PG-Reductase
  • 13-15-Ketoprostaglandin Reductase, delta
  • 13-Reductase, 15-Ketoprostaglandin delta
  • 13-Reductase, 15-Oxoprostaglandin
  • 15 Ketoprostaglandin delta 13 Reductase
  • 15 Oxoprostaglandin 13 Reductase
  • Prostaglandin 13,14 Reductase
  • Prostaglandin delta 13 Reductase
  • Reductase, delta 13-15-Ketoprostaglandin
  • delta 13 15 Ketoprostaglandin Reductase
  • delta 13 PG Reductase
  • delta 13-Reductase, 15-Ketoprostaglandin
  • delta-13-Reductase, Prostaglandin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

94; was PROSTAGLANDIN-13,14-REDUCTASE 1978-93 (see under OXIDOREDUCTASES 1978-90); DELTA 13-15-KETOPROSTAGLANDIN REDUCTASE was (NM) 1976-93; PROSTAGLANDIN DELTA 13 REDUCTASE was (NM) 1981-93

MeSH Record

Previous Indexing

  • Oxidoreductases (1966-1977)
  • Prostaglandins (1966-1977)
  • specific prostaglandin (1975-1977)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.660.490

AMA Style

References

  1. National Library of Medicine. 15-Oxoprostaglandin 13-Reductase. Medical Subject Headings (MeSH). 2026. Unique ID D011452. http://id.nlm.nih.gov/mesh/2026/D011452
  2. 15-Oxoprostaglandin 13-Reductase. In: Wikidata. https://www.wikidata.org/wiki/Q21134201