Chemicals and Drugs

1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester 3-Pyridinecarboxylic acid

A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.

Chemical Identity

Chemical Information

Molecular Formula
C16H15F3N2O4
Molecular Weight
356.30 g/mol
CAS Registry No.
71145-03-4
IUPAC Name
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
InChIKey
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
SMILES
CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
MeSH Unique ID
D001498
Source
PubChem CID 2303

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
  • BK-8644
  • Bay R5417
  • Bay-K-8644
  • Bay-K-8644, (+)-Isomer
  • Bay-K-8644, (+-)-Isomer
  • Bay-K-8644, (-)-Isomer
  • Bay-K8644
  • Bay-R-5417
  • BK 8644
  • BK8644
  • Bay K 8644
  • Bay K8644
  • Bay R 5417
  • BayK8644
  • BayR5417
  • R5417, Bay

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a calcium channel agonist

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Nifedipine/analogs & derivatives (1975-1986)
  • Pyridines (1966-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.725w.203.600w
  2. D03w.383.725w.547w.900w

AMA Style

References

  1. National Library of Medicine. 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester 3-Pyridinecarboxylic acid. Medical Subject Headings (MeSH). 2026. Unique ID D001498. http://id.nlm.nih.gov/mesh/2026/D001498
  2. 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester 3-Pyridinecarboxylic acid. In: Wikipedia. https://en.wikipedia.org/wiki/Bay_K8644
  3. 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester 3-Pyridinecarboxylic acid. In: Wikidata. https://www.wikidata.org/wiki/Q4874027
  4. 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester 3-Pyridinecarboxylic acid. In: PubChem Compound. CID 2303. https://pubchem.ncbi.nlm.nih.gov/compound/2303