Chemicals and Drugs

11-beta-Hydroxysteroid Dehydrogenase Type 2

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

7 entry terms
  • 11 beta-HSD2
  • 11 beta-Hydroxysteroid Dehydrogenase Type 2
  • 11beta-HSD2
  • 11beta-HSD2 Reductase
  • 11beta-Hydroxysteroid Dehydrogenase Type 2
  • 11 beta Hydroxysteroid Dehydrogenase Type 2
  • 11beta Hydroxysteroid Dehydrogenase Type 2

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003

MeSH Record

Previous Indexing

  • Hydroxysteroid Dehydrogenases (1992-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.047w.436w.174w.600
  2. D08.811w.682w.047w.820.100w.600

AMA Style

References

  1. National Library of Medicine. 11-beta-Hydroxysteroid Dehydrogenase Type 2. Medical Subject Headings (MeSH). 2026. Unique ID D043209. http://id.nlm.nih.gov/mesh/2026/D043209
  2. 11-beta-Hydroxysteroid Dehydrogenase Type 2. In: Wikidata. https://www.wikidata.org/wiki/Q2807192